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Lorenzo Di Rienzo

Post Doc
Nanotechnologies for Neurosciences
Research center

My research focuses on the quantitative characterization of physical mechanisms underlying molecular recognition between biomolecules. This aspect is investigated by analyzing the structural and dynamic features of biomolecules. The findings in this field are meant to allow the development of predictive algorithms regarding elements of relevant biomedical importance, such as protein engineering or biological macromolecules binding site identification.


Title: PhD in Life Sciences
Institute: Sapienza Università di Roma
Location: Rome
Country: Italy
From: 2015 To: 2018

All Publications
Grassmann G., Miotto M., Di Rienzo L., Gosti G., Ruocco G., Milanetti E.
A novel computational strategy for defining the minimal protein molecular surface representation
PLoS ONE, vol. 17, (no. 4 April)
Di Rienzo L., De Flaviis L., Ruocco G., Folli V., Milanetti E.
Binding site identification of G protein-coupled receptors through a 3D Zernike polynomials-based method: application to C. elegans olfactory receptors
Journal of Computer-Aided Molecular Design, vol. 36, (no. 1), pp. 11-24
Miotto M., Di Rienzo L., Gosti G., Bo' L., Parisi G., Piacentini R., Boffi A., Ruocco G., Milanetti E.
Inferring the stabilization effects of SARS-CoV-2 variants on the binding with ACE2 receptor
Communications Biology, vol. 5, (no. 1)
Piacentini R., Centi L., Miotto M., Milanetti E., Di Rienzo L., Pitea M., Piazza P., Ruocco G., Boffi A., Parisi G.
Lactoferrin Inhibition of the Complex Formation between ACE2 Receptor and SARS CoV-2 Recognition Binding Domain
International Journal of Molecular Sciences, vol. 23, (no. 10)
De Lauro A., Di Rienzo L., Miotto M., Olimpieri P.P., Milanetti E., Ruocco G.
Shape Complementarity Optimization of Antibody–Antigen Interfaces: The Application to SARS-CoV-2 Spike Protein
Frontiers in Molecular Biosciences, vol. 9